320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study explores the relationship between myocardial fibrosis and patient outcomes in Atrial Fibrillation (AF), specifically after catheter ablation. It aims to use Cardiac CT, an accessible tool, to measure left ventricular extracellular volume (ECV) as an indicator of fibrosis. The study will assess if higher ECV levels correlate with increased risks of AF recurrence, hospitalization, and poor cardiac function recovery. Positive findings could make ECV a key factor in deciding AF treatment strategies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Healthy Volunteers: f
View:

• Patients must be at least 21 years old at the time of enrollment.

• Patients must be able to give informed consent.

• Patients with symptomatic paroxysmal/persistent atrial fibrillation (AF).

• Eligible patients must be determined to be suitable candidates for ablation to treat AF by their cardiologist and/or electrophysiologists regardless of this protocol.

• Patients are scheduled to have a pre-procedure cardiac CT upon the discretion of their electrophysiologists

Locations
United States
Maryland
Johns Hopkins Hospital
RECRUITING
Baltimore
Contact Information
Primary
Konstantinos Aronis, MD PHD
karonis1@jhmi.edu
2017169226
Time Frame
Start Date: 2025-04-10
Estimated Completion Date: 2026-04-01
Participants
Target number of participants: 100
Treatments
Other: Afib with ECV measurement
patients who are referred for catheter ablation will undergo additional CT acquisition for measurement of ECV to determine if there is any association between ECV expansion and Afib burden.
Related Therapeutic Areas
Sponsors
Leads: Johns Hopkins University
Collaborators: Canon Medical Systems, USA

This content was sourced from clinicaltrials.gov